Guided bone regeneration of chronic non‐contained bone defects using a volume stable porous block TiO2 scaffold: An experimental in vivo study

Objectives To evaluate new lateral bone formation and volume augmentation by guided regeneration (GBR) in chronic non-contained defects with the use of a non-resorbable TiO2-block. Materials methods Three buccal were created each hemimandible eight beagle dogs allowed to heal for 8 weeks before treatment GBR. Each was randomly allocated 4- or 12-week healing time after GBR, three intervention groups assigned block randomization: TiO2 block: TiO2-scaffold collagen membrane, DBBM particles: Deproteinized bovine mineral (DBBM) Empty control: Collagen membrane only. Microcomputed tomography (microCT) used measure width augmentation. Histological outcomes included descriptive analysis histomorphometric measurements. Results MicroCT demonstrated increasing from 4 12 healing. The greatest mineralized seen empty controls, largest observed sites. particles more grafted area than blocks, but small amounts less control Conclusion blocks rendered also compared particles. most outward defect margins indicating that presence either graft material leads slow appositional growth.